Apoptosis in Granulosa cells during follicular atresia: relationship with steroids and insulin-like growth factors
نویسندگان
چکیده
منابع مشابه
miR-26b Promotes Granulosa Cell Apoptosis by Targeting ATM during Follicular Atresia in Porcine Ovary
More than 99% of ovarian follicles undergo atresia in mammals, but the mechanism of follicular atresia remains to be elucidated. In this study, we explored microRNA (miRNA) regulation of follicular atresia in porcine ovary. A miRNA expression profile was constructed for healthy, early atretic, and progressively atretic follicles, and the differentially expressed miRNAs were selected and analyze...
متن کاملExpression of inhibitor of apoptosis proteins (IAPs) in rat granulosa cells during ovarian follicular development and atresia.
The inhibitor of apoptosis proteins (IAPs) constitute a family of highly conserved apoptosis suppressor proteins that was originally identified in baculoviruses. Although IAP homologs have been recently identified and demonstrated to suppress apoptosis in mammalian cells, their expression and role during follicular development and atresia are unknown. The present study was conducted to address ...
متن کاملChanges in follicular fluid steroids, insulin-like growth factors (IGF) and IGF-binding protein concentration, and proteolytic activity during equine follicular development.
The objective of the present study was to evaluate changes in equine follicular fluid insulin-like growth factor binding protein (IGFBP) proteolytic activity as well as steroid, IGF, and IGFBP concentrations during follicular development in the mare. Mares (n = 14) were classified as either in the follicular phase (n = 8) or luteal phase (n = 6). Follicles (n = 92) were categorized as small (6 ...
متن کاملInsulin-like growth factors during pregnancy
© 1999 Journals of Reproduction and Fertility 1359-6004/99 $15.00 The insulin-like growth factors, IGF-I and IGF-II, have effects on metabolism, growth, proliferation and differentiation in many tissues and cell types (Jones and Clemmons, 1995) and are therefore important modulators of many aspects of physiology. Insulin-like growth factor actions are largely mediated via the type 1 IGF recepto...
متن کاملApoptosis and Ovarian Follicular Atresia in Mammals
The reproductive performance of any mammalian species can be enhanced by enriching nutrition, regulating environmental factors like photoperiod, temperature, humidity etc., through selective breeding, endocrine manipulations and better management practices (Sharma, 2000; Maillet et al., 2002; Bussiere et al., 2002; Iwata et al., 2004, 2005; Rudolf, 2007; Bhardwaj and Sharma, 2011). The endocrin...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2004
ISSN: 1001-0602,1748-7838
DOI: 10.1038/sj.cr.7290234